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OnabotulinumtoxinA (OBTA, Botox) is also approved for the treatment ofpain associated with chronic migraine and for the treatment of upper limb spasticity inadult patients. These experiments are inappropriate for study-ing independent variables that can be continuously manipulated, especially when examin-ing nonlinear functions. A cross-sectional view reveals a characteristic con-figuration ofnine pairs or doublets ofcircularly arranged mi-crotubules surrounding two central microtubules (Fig

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