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The integrity of the mitochondrion isbreached, the mitochondrial transmembrane potentialdrops, and the electron-transport chain is disrupted.Proteins from the mitochondrial intermembrane space,such as cytochrome c and SMAC/DIABLO (sec-ond mitochondria-derived activator of caspases/directinhibitor ofapoptosis-binding protein with low isoelectricpoint [pi]) are released into the cytoplasm to activate acascade of proteolytic enzymes called caspases that areresponsible for dismantling the cell. Meulmeester E et al (2005) ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabiliza-tion by HAUSP in favor of p53 activation. In periprosthetic hip and knee infections, these parametershave a high sensitivity, only if normal values are defined as threshold (reviewed in )(see Chapter 9).
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